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Overview Cancer and vitamin D

Table of contents


Scores of studies show that Vitamin D prevents many cancers and treats a few cancers

  • Prevention results from 2,000 to 5,000 IU of vitamin D
    Prevention really depends on the level of vitamin D in the blood, and some vitamin D-deficient groups need much more
  • Treatment needs > 8,000 IU of vitamin D
    But must be careful, as vitamin D makes some Chemotherapy more potent

A high percentage of all cancer deaths are prevented by a high enough level of vitamin D in your bloodstream

derived from Grassroots 2013


VitaminDWiki – Cancer category contains


Cancers get less Vitamin D when there is a poor Vitamin D Receptor


VitaminDWiki has 980+ studies with Cancer etc. in the title

CANCER OR LYMPHOMA OR LEUKEMIA OR MYLENOMA OR Osteosarcoma OR Adenocarcinoma


VitaminDWiki - 87+ VDR pages have CANCER in the title


Vitamin D fights cancer in many ways - GrassrootsHealth Sept 2022

How Vitamin D Works to Help Prevent Cancer

  • Inhibits cancer cell growth and proliferation
  • Reduces cancer metastasis
  • Stimulates maturation of healthy cells (differentiation)
  • Induces death of cancer cells (apoptosis or programmed cell death)
  • Prevents blood vessel growth in tumors (angiogenesis)
  • Prevents inflammation associated with cancer
  • Reduces the risk of incidence and/or death due to cancer

See also (VitaminDWiki)

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499 Cancer Intervention Trials with Vitamin D as of Nov 2024

ClinicalTrials.gov


46+ VitaminDWiki pages have both CANCER AND RCT in the title

The list is automatically updated

Items found: 43
Title Modified
Following Digestive Cancer 2,000 IU of Vitamin D were given. Those whose Omega-3 levels rose had fewer Cancer problems – RCT March 2024 25 Mar, 2024
50,000 IU of Vitamin D weekly greatly decreased bone loss from prostate cancer therapy - RCT March 2024 24 Mar, 2024
Cancers reduced after 2 years of 2000 IU Vitamin D daily (2nd RCT) – RCT Aug 03 Nov, 2023
Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023 13 Aug, 2023
After Colorectal Cancer Surgery the immune system was maintained by Vitamin D (8,000 IU daily) – RCT Jan 2023 03 Jan, 2023
Colorectal Cancer – vitamin D did not help (too small of a response) – RCT Oct 2022 29 Oct, 2022
Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018 13 Jun, 2022
2.5 X reduced risk of cancer in 70 year-olds by a small amount of Vitamin D, Omega-3 and exercise – RCT April 2022 25 Apr, 2022
Breast Cancer not prevented by 1,000 IU of Vitamin D (no surprise) – RCT Aug 2021 14 Apr, 2022
Rectal Cancer genes down-regulated by Vitamin D (3,200 IU only helped some) – RCT Aug 2021 03 Aug, 2021
Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019 25 Jul, 2021
Digestive Tract Cancer survival increased 3X if 2,000 IU of vitamin D and have high level of PD-L1 – RCT June 2021 29 Jun, 2021
2,000 IU of vitamin D and Omega-3 reduced Cancer death rate bv 40% (normal weight) – VITAL RCT Nov 2020 03 Dec, 2020
2 X better survival of digestive cancer if 2,000 IU of Vitamin D plus good VDBP gene – RCT Feb 2020 04 Feb, 2020
Digestive track Cancer (poorly differentiated) death 4X less likely if 2,000 IU of vitamin D – RCT Oct 2019 29 Oct, 2019
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 05 Jul, 2019
Omega-3 reduced by 4X the interruption of Cervical Cancer chemotherapy due to toxicity – RCT June 2019 18 Jun, 2019
Variety of Vitamin D forms treat Prostate Cancer – RCT Review April 2019 01 May, 2019
Vitamin D does not treat colon cancer (when you only use 1,000 IU) – RCT April 2019 13 Apr, 2019
Digestive tract cancer death rates reduced a bit by a bit of vitamin D – RCT April 2019 10 Apr, 2019
Advanced Colorectal Cancer survival is increased somewhat with 4,000 IU of vitamin D – RCT April 2019 10 Apr, 2019
Esophageal Cancer surgery helped by 300,000 IU of Vitamin D – RCT Sept 2018 18 Sep, 2018
Lung cancer treated by Vitamin D (1200 IU early stage) – RCT July 2018 04 Sep, 2018
Following breast cancer 100K IU Vitamin D doses twice a month helped a lot – RCT July 2016 31 Dec, 2017
Prostate Cancer might be treated by 4,000 IU of vitamin D and aspirin – RCT 2021 28 Nov, 2017
Lymphoid cancer deaths cut in half with 400 IU of vitamin D and 1 gram of Calcium (WHI) – RCT Nov 2017 04 Nov, 2017
Prostate Cancer treatment (Vitamin D, Omega-3, Tumeric) RCT ending Dec 2018 26 Sep, 2017
Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017 19 Aug, 2017
Risk of Colon Cancer can be doubled or halved by genes – RCT May 2017 19 Aug, 2017
Breast Density and Cancer not reduced by Vitamin D (only used 3,000 IU) - RCT July 2017 18 Jul, 2017
Modeling Cancer RCTs – including Breast Cancer – April 2017 03 May, 2017
Cancer risk in older women reduced 32 percent by 2,000 IU of Vitamin D plus Calcium – 4 year RCT Oct 2016 12 Oct, 2016
Sunscreen used daily vs discretionary: no difference in skin cancer rate – RCT 2016 06 Aug, 2016
Colon Cancer proven again to not be treated by just 1000 IU of vitamin D – RCT Oct 2015 20 Oct, 2015
2000 IU of vitamin D reduced fatigue of advanced cancer – RCT May 2012 03 Sep, 2015
Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012 24 May, 2015
Breast Cancer is prevented by vitamin D – but more RCT are needed to understand why – April 2015 15 Apr, 2015
Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015 02 Apr, 2015
Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D – July 2013 16 Nov, 2014
Mayo clinic starting Cancer RCT using grossly inadequate 2,000 IU of vitamin D – Sept 2013 04 Dec, 2013
Can take 40,000 IU of vitamin D daily before prostate cancer surgery – RCT March 2013 18 Jun, 2013
Vitamin D Supplementation and Cancer - Review of RCT Jan 2013 06 Dec, 2012
3 weeks of Vitamin D can not help much (Breast Cancer surgery in this case) – RCT Aug 2019 No value for 'modification_date_major'

55% Cancer increase in young adults in 30 years in middle-income countries - 2023

The unexplained rise of cancer among millennials
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They suspect the increase is due to Ultra-processed food ==> poor gut biome
VitaminDWiki additionally suspects herbicides & pesticides ==> poor gut biome


VitaminDWiki - 10 Infant-Child pages with CANCER in the title

This list is automatically updated

Items found: 15

259 Cancer – Breast items

which includes


145 Cancer – Colon items

which includes


103 Cancer - Prostate items

which includes


58 Cancer - Pancreatic items

which include


55 Cancer – Lung items

which includes


113 Cancer – After items

which includes


121 Cancer – Skin items

which includes


26 Cancer – Lymphoma items

which includes


295 Cancer – General items

which includes


37+ VitaminDWiki Mortaility pages have CANCER in the title

The list is automatically updated

Items found: 39
Title Modified
Pancreatic cancer mortality 28% more likely if low vitamin D – meta-analysis Jan 2024 28 Nov, 2024
3 Cancers have higher mortality if high PTH (which can be lowered by Vitamin D) - Aug 2024 15 Aug, 2024
Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024 01 May, 2024
People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023 23 Nov, 2023
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 31 Jul, 2023
Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023 01 May, 2023
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 30 Apr, 2023
Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 03 Jul, 2022
Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 15 Oct, 2021
Cancer mortality not reduced by small vitamin D doses - Sept 2021 21 Sep, 2021
Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 17 Aug, 2021
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 10 Jan, 2021
Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 31 Dec, 2020
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 09 Nov, 2020
Cancer is leading cause of death - Vitamin D and Receptor activators help 09 Nov, 2019
Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 08 Nov, 2019
Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 10 Sep, 2019
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 05 Jul, 2019
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 05 Jul, 2019
Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 07 May, 2019
Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 13 Apr, 2019
Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 26 Nov, 2018
Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival 10 Sep, 2018
The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 13 Jan, 2018
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 29 Dec, 2017
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 13 Jun, 2017
Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 15 Jun, 2016
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 09 Nov, 2014
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 30 Sep, 2014
Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 17 Jun, 2014
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 12 May, 2014
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 08 May, 2014
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 08 Apr, 2014
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 06 Mar, 2014
Vitamin D and Cancer Mortality – review Jan 2013 17 Sep, 2013
Mortality and Cancer varies with latitude in France too – 2010 26 Oct, 2012
More US deaths due to cancer than heart if dark skinned – Sept 2012 18 Sep, 2012
Lack of solar UVB in US is associated with some Cancers - 2006 28 Dec, 2011
Solar radiation, vitamin D and cancer incidence and mortality in Norway 13 Apr, 2010

Following graph from the CDC August 2010

from PDF in File Gallery - More about vitamin D, also wiki
CLICK HERE for Original study by Lappe - 2007
41 minutes good video of Lappe explaining the trial
in which she mentions the next 5-year trial underway with 2,000 IU of vitamin D
Breast Cancer details from the study
For years 2-4
Placebo: 8 Breast Cancers out of 266 women
1100 IU vitamin D + Calcium 4 Breast Cancers out of 403 women
That is 8/266 ==> 4/403 with vitamin D
So roughly 3% ==> 1% with 1100 IU of vitamin D
about a 3X reduction for Breast Cancer(vs 4X reduction for all Cancers)
CLICK HERE for Lappe -2011 slide description of the original study
See wikipage:http://www.vitamindwiki.com/tiki-index.php?page_id=931


Colon Cancer Chart: Vitamin D > 40ng is good

BISCHOFF April-2010  PDF


Increase in Childhood Cancer in recent decades

Childhood Cancer Increase


Cancer $creening Doesn't Save Lives, 2 Meta-Analyses 2015, 2023

Cancer $creening Doesn't Save Lives, Meta-Study Reveals
The huge problem of false positives/overdiagnosis GreenMedInfo Jan 2015

  • Estimated Lifetime Gained With Cancer Screening Tests: A Meta-Analysis of Randomized Clinical Trials - Sept 2015 - doi: 10.1001/jamainternmed.2023.3798
    • "Conclusions and relevance: The findings of this meta-analysis suggest that current evidence does not substantiate the claim that common cancer screening tests save lives by extending lifetime, except possibly for colorectal cancer screening with sigmoidoscopy."
    • Can be read at DeepDyve

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The Impact of Vitamin D in Cancer - book chapter - 2017

 Download the PDF from VitaminDWiki


Alternative therapies have worse outcomes when cancer therapy is ignored - July 2018

Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers
Skyler B. Johnson, MD1; Henry S. Park, MD, MPH1; Cary P. Gross, MD2; et al James B. Yu, MD, MHS1,2
JAMA Oncol. Published online July 19, 2018. doi:10.1001/jamaoncol.2018.2487
 Download the PDF from VitaminDWiki
"Vitamin D" does not occur once in the study
Note: The study only looks at
Cancer treatment, not prevention
Cancer mortality, not cancer survival


Cancer Treatment 101: A Primer for Non-Oncologists - Aug 2024 (nothing about vitamin D)

MedScape


Cancer Factoids from The Body, by Bill Bryson, 2019

  • They (Cancers) have evolved to avoid detection,” says Vormoor. “They can hide from drugs. They can develop resistance. (VitaminDWiki also believes that many have also learned to hide.
  • Something we have only recently realized is that before cancers metastasize, they are able to prepare the ground for an invasion in distant target organs, probably through some form of chemical signaling. “What this means,” Vormoor says, “is that when cancer cells spread to other organs, they don’t just turn up and hope for the best. They already have a base camp.
  • Viruses and bacteria cause cancers, too. The World Health Organization 2011 estimated that 6 percent of cancers in the developed world but 22 percent in low- and middle-income countries are attributable to viruses alone.
  • A significant fraction of childhood cancer deaths come not from the cancer itself but from the treatments for it.

Aloe appears to help with Cancer chemo and radiation therapy - Greger - July 2022

Aloe Is Put to the Test Against Cancer
Also mentions Aloe treating eye cancer in an individual - without any surgery or other treatment.
Note: The wife of the founder of VitaminDWiki used several aloe plants to treat her Breast Cancer radiation therapy burns about 20 years ago.


Cancer Incidence in Men and Women, and Vitamin D ( 2022)

CancerMenWomen Vitamin D
Bladder 1 in 26 1 in 86D
Colorectal 1 in 24 1 in 25D
Lung 1 in 16 1 in 17 D
Melanoma 1 in 27 1 in 40D
Pancreatic 1 in 49 1 in 61D
Prostate 1 in 8 -D
Breast- 1 in 8D
Uterine- 1 in 32
Thyroid? 1 in 55 D
Ovarian - 1 in 85D

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Overview Cancer and vitamin D        
131835 visitors, last modified 17 Nov, 2024,
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Attached files

ID Name Comment Uploaded Size Downloads
20077 Cancer Screening.jpg admin 07 Sep, 2023 21.17 Kb 701
19676 Cancer rates vs income.jpg admin 20 Jun, 2023 26.87 Kb 853
19674 Increase cancer ty type.jpg admin 20 Jun, 2023 56.07 Kb 863
19673 Cancer - young - overall rate.jpg admin 20 Jun, 2023 54.70 Kb 869
18444 Cancer GRH.jpg admin 19 Sep, 2022 178.41 Kb 1716
10235 jamaoncology_Johnson_2018_oi_180051.pdf admin 23 Jul, 2018 225.37 Kb 2466
7879 Cancer Chapter - 2017.pdf admin 25 Mar, 2017 461.98 Kb 1766